Physical Brain Change

Imaging Research on BrainHQ

When brain function improves, it generally reflects a change in the brain itself. Parts of the brain can grow larger, neurons can move more quickly or in better coordination, and so on. Seventeen imaging studies have taken a look inside the brain, and shown that there were measureable changes in the brains of people who used exercises in BrainHQ. This is important: these studies don’t just show that people do better on tests of cognitive function, nor do they rely on what people say about how sharp they feel. Instead, the brain imaging actually shows differences in the brain after training that often correlate to the improvements the people experience in their brain function.

 

  • One study on BrainHQ’s auditory exercises showed that the brain’s neural timing improves with training, with neurons responding more quickly to speech. This improvement in the brain correlated to improvements in cognitive and perceptual skills (memory, speed of processing, and speech-in-noise perception).
  • Two EEG studies have measured amplitude to show that using a series of BrainHQ’s visual exercises can improve visual perception and reverse declines in selective attention for better memory and other cognitive capabilities.
  • Another imaging study showed that training with a selection of BrainHQ’s exercises changed the integrity of occipito-temporal white matter, which was associated with better problem-solving and reasoning.
  • fMRI data showed training-related activation in areas associated with orienting visual attention.
  • A study using EEG matched training-induced modifications in early visual processing in the brain to improvements in memory.

 

Information and citations for imaging studies on BrainHQ

“Reversal of age-related neural timing delays with training”
Published in: Proceedings of the National Academy of Sciences
Lead Author: Samira Anderson, PhD, Northwestern University
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“Training changes processing of speech cues in older adults with hearing loss”
Published in: Frontiers in Systems Neuroscience
Lead Author: Samira Anderson, PhD, Northwestern University
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“Partial maintenance of auditory-based cognitive training benefits in older adults”
Published in: Neuropsychologia
Lead Author: Samira Anderson, PhD, Northwestern University
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“Cognitive and physical training for the elderly: Evaluating outcome efficacy by means of neurophysiological synchronization”
Published in: International Journal of Psychophysiology
Lead Author: Christos A. Frantzidis, Aristotle University of Thessaloniki (Greece)
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“Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: An eLORETA controlled study on resting states”
Published in: Neural Plasticity
Lead Author: Charis Styliadis, Aristotle University of Thessaloniki (Greece)
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“The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia”
Published in: Psychiatry Research: Neuroimaging
Lead Author: Christine I. Hooker, PhD, Harvard University 
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“Neural plasticity underlying visual perceptual learning in aging”
Published in: Brain Research
Lead Author: Jyoti Mishra, PhD, University of California, San Francisco 
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“Cognitive training and selective attention in the aging brain: An electrophysiological study”
Published in: Clinical Neurophysiology
Lead Author: Jennifer L. O’Brien, PhD, University of South Florida 
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“Adjusting brain dynamics in schizophrenia by means of perceptual and cognitive training”
Published in: PLoS One
Lead Author: Tzvetan Popov, University of Konstanz (Germany) 
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“Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study”
Published in: Journal of Alzheimer’s Disease
Lead Author: Allyson C. Rosen, PhD, Stanford University
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“The neural correlates of an expanded functional field of view”
Published in: Journals of Gerontology Series B
Lead Author: Paige E. Scalf, PhD, University of Arizona
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“A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly”
Published in: Translational Psychiatry
Lead Author: Tejal Shah, University of Western Australia
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“Neurocognitive enhancement in older adults: Comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity”
Published in: NeuroImage
Lead Author: Maren Strenziok, PhD, George Mason University
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“Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia”
Published in: Neuron
Lead Author: Karuna Subramaniam, PhD, University of California, San Francisco
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“Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?”
Published in: Biological Psychiatry
Lead Author: Sophia Vinogradov, PhD, University of California, San Francisco
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“The influence of perceptual training on working memory in older adults”
Published in: PLoS One
Lead Author: Anne S. Berry, PhD, University of California, Berkeley
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“Neuroscience-informed auditory training in schizophrenia: A final report of the effects on cognition and serum brain-derived neurotrophic factor”
Published in: Schizophrenia Research: Cognition
Lead Author: Sophia Vinogradov, PhD, University of California, San Francisco
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“Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eloreta controlled study on resting states”
Published in: Neural Plasticity
Lead Author: Panagiotis Bamidis, PhD, Aristotle University of Thessaloniki
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“Nurse-enhanced computerized cognitive training increases serum brain-derived neurotropic factor levels and improves working memory in heart failure”
Published in: Journal of Cardiac Failure
Lead Author: Bruno J Giordani, PhD, University of Michigan School of Nursing, Ann Arbor, Michigan
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“Targeted training modifies oscillatory brain activity in schizophrenia patients”
Published in: NeuroImage
Lead Author: Brigitte Rockstroh, PhD, University Konstanz, Germany
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“Neural plasticity underlying visual perceptual learning in aging”
Published in: Brain Research
Lead Author: Jyoti Mishra, PhD, University of California, San Francisco 
View abstract